Raman-spectroscopic detection in miniaturized free-flow-electrophoresis

At present, the monitoring of chemical and biological production and cleaning processes as well as analytical methods at medical diagnostics in most instances are based on “offline”-methods. Here, samples are taken out of the processes; they are analyzed to their substances at appropriate equipped laboratories by chemical, biochemical or physical methods (for example chromatography, mass spectroscopy or immunoassays). Most of these standard analyzing-techniques are not able to execute continuous analyses directly in process (online). The common “offline”-laboratory-analytics are time consuming, expensive and labor-intensive. Therefrom, very high risks emerge by tardily detected contamination, especially at the production of sensitive and valuable goods e.g. in the domains of pharmaceutical products, chemicals or foods and environmental analytics. As a result, whole product charges may drop. This should be prevented by the use of online analyzing and monitoring methods for chemical and biological processes.